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KMID : 0387419990100010001
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Korean Society of Oriental Neuropsychiatry
1999 Volume.10 No. 1 p.1 ~ p.15
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The effects of Sahyangsohapwon on Learning and Memory of AD Rats using Morris water maze and Radial arm maze paradigm
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Abstract
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The effects of Sahyangsohapwon on the enhancement of learning and memory of AD model rats were studied with Morris water maze and radial arm maze. Sample group was electrolytically lesioned on nbM, and then daily treated with the medicine for two months. Control group with nbM lesion, and sham group with the sham operation were treated the vehicle for same duration. The following results were observed.
1. In the learning trials of Morris water maze, all three groups were improved in learning capacity as trials were repeated, but the sham group showed more prominent improvement in learning compared with the control group(p〈0.01).
2. In memory retention test of Morris water maze, the sham group marked more significant improvement statistically in memory retention compared with the control group(p〈0.05).
3. In the learning of radial arm maze, the sham group shows better learning capacity significantly compared with the control group(p〈0.05).
With the experimental results above, Sahyangsohapwon can be supposed to have the improving effects on the learning and memory of AD rats induced by electronical injury of nbM.
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KEYWORD
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